Research AREAS

Heart rate variability and outcomes

  • Cardiac and non-cardiac mortal dementia
  • Survival with heart failure
  • Survival after myocardial infarction (MI)
  • Transplant-free survival in chronic obstructive pulmonary disease (COPD)
  • Length of stay after abdominal aortic aneurysm surgery
  • Mortality in intensive care patients
  • Atrial fibrillation after cardiac surgery
  • HRV measured during polysomnography and mortality in older adults
  • Changes in HRV over time and mortality in older adults
  • HRV and sudden death in sickle cell anemia

Factors affecting heart rate variability

  • Age
  • Gender
  • Race
  • Pregnancy
  • Clinical and demographic factors post-MI
  • Pet ownership
  • CABG
  • Diabetes
  • Insulin resistance
  • Fish oil consumption
  • Inflammatory markers
  • Markers of coagulation
  • Treatment of depression in cardiac patients
  • Sickle cell anemia
  • Valvular disease

Depression in cardiac patients

  • Effect of depression on HRV post-MI
  • Effect of depression on HRV in heart failure
  • Effect on HRV of treatment for depression in cardiac patients
  • HRV during sleep and depression in cardiac patients
  • Effects of Pharmacologic Therapy on HRV
  • Dexmedetomidine
  • Digoxin
  • Dobutamine stress echocardiography
  • Enalapril
  • Encainide
  • Flecainide
  • Labetalol
  • Moricizine
  • Nicotine replacement therapy and smoking cessation
  • Normodyne
  • Pindolol
  • Statins
  • Visken

Non-pharmacologic interventions and HRV

  • Exercise training
  • Coronary artery bypass surgery
  • Lung volume reduction surgery
  • Erratic Sinus Rhythm and Other Abnormal Heart Rate Patterns
  • Detection of erratic sinus rhythm
  • Effect of erratic sinus rhythm on HRV for risk stratification in the elderly
  • Association of erratic sinus rhythm and mortality in the elderly
  • Association of erratic sinus rhythm and mortality post-MI
  • Effect of pharmacologic therapy on erratic rhythm
  • Clinical significance of oscillating heart rate patterns
  • T-wave Alternans
  • Association with sudden cardiac death in older adults
  • Association with sudden cardiac death post-MI
  • Association with cardiac mortality post-MI
  • Relationship to depression in post-MI patients
  • Sleep
  • Relationship of HRV and sleep stages in older adults
  • Relationship of HRV by sleep stage and normal and pathological aging.
  • Relationship of HRV by sleep stage with dementia in older adults
  • Circadian rhythms of heart rate and HRV during sleep.

Sleep-disordered breathing

  • Holter-based screening for sleep-disordered breathing
  • Continuous ECG-based detection of periodic breathing
  • Measurement of cyclic variation of heart rate parameters
  • Relationship of cyclic variation of heart rate parameters and sleep-disordered breathing in older adults
  • Relationship of cyclic variation of heart rate parameters and mortality in older adults
  • Relationship of periodic breathing heart rate patterns and sudden cardiac death
  • Relationship of periodic breathing heart rate patterns and atrial fibrillation after cardiac surgery
  • Relationship of cyclic variation of heart rate and sleep-disordered breathing in depressed and non-depressed cardiac patients